Will Oregon cruise into Michigan? Ohio State or Penn State? Our CFB tips for week 10

Week 10 of the college football season brings two top matchups in the Big Ten, with third-ranked Penn State hosting No. 4 Ohio State and the top-ranked Oregon Ducks visiting the Big House to take on Michigan.

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Both away teams are favorites, but will the Ducks cover the 14.5-point lead in Ann Arbor and remain undefeated? And will the Buckeyes win at Beaver Stadium – another hostile environment – ​​and hand the Nittany Lions their first loss of the season?

Other exciting Big Ten matchups this week include: 24th-ranked Minnesota, Illinois; No. 13 Indiana at Michigan State; Wisconsin at Iowa; and USC in Washington.

Check out this week's college football odds and score predictions for select games from the CFB coverage team at The Oregonian/OregonLive.

No. 1 Oregon (8-0, 5-0) at Michigan (5-3, 3-2)

Game details: 12:30 p.m. PT Saturday at Michigan Stadium in Ann Arbor

TV channels and live stream: CBS and Paramount+

Latest line: Oregon until May 14th

Over/Under: 44.5

Predictions

Ryan Clarke: Oregon 31, Michigan 13

James Crepea: Oregon 35, Michigan 14

Nick Daschel: Oregon 31, Michigan 27

Aaron Fentress: Oregon 33, Michigan 13

Joe Freeman: Oregon 35, Michigan 17

Sean Meagher: Oregon 38, Michigan 20

Joel Odom: Oregon 38, Michigan 24

Bill Oram: Oregon 33, Michigan 21

No. 4 Ohio State (6-1, 3-1) and No. 3 Penn State (7-0, 4-0)

Game details: 9 a.m. PT Saturday at Beaver Stadium in University Park, Pennsylvania

TV channels and live stream: Fox and Fox Sports Live

Latest line: Ohio State by 3

Over/Under: 46.5

Predictions

Ryan Clarke: Ohio State 27, Penn State 20

James Crepea: Ohio State 28, Penn State 27

Nick Daschel: Ohio State 23, Penn State 20

Aaron Fentress: Ohio State 27, Penn State 23

Joe Freeman: Ohio State 27, Penn State 24

Sean Meagher: Penn State 28, Ohio State 27

Joel Odom: Ohio State 34, Penn State 31

Bill Oram: Penn State 20, Ohio State 17

Minnesota (5-3, 3-2) at No. 24 Illinois (6-2, 3-2)

Game details: 9 a.m. PT Saturday at Memorial Stadium in Champaign, Illinois

TV channels and live stream: FS1 and Fox Sports Live

Latest line: Minnesota at 3

Over/Under: 45.5

Predictions

Ryan Clarke: Illinois 28, Minnesota 17

James Crepea: Illinois 28, Minnesota 24

Nick Daschel: Illinois 27, Minnesota 21

Aaron Fentress: Illinois 24, Minnesota 22

Joe Freeman: Minnesota 23, Illinois 20

Sean Meagher: Illinois 34, Minnesota 24

Joel Odom: Minnesota 19, Illinois 16

Bill Oram: Illinois 28, Minnesota 16

Northwestern (3-5, 1-4) at Purdue (1-6, 0-4)

Game details: 9 a.m. PT Saturday at Ross-Ade Stadium in West Lafayette, Indiana

TV channels and live stream: Big Ten Network and Fox Sports Live

Latest line: Purdue by 1.5

Over/Under: 44.5

Predictions

Ryan Clarke: Northwestern 20, Purdue 18

James Crepea: Northwestern 31, Purdue 21

Nick Daschel: Northwest 30, Purdue 27

Aaron Fentress: Purdue 25, Northwestern 23

Joe Freeman: Northwestern 23, Purdue 20

Sean Meagher: Northwestern 27, Purdue 14

Joel Odom: Northwestern 30, Purdue 24

Bill Oram: Northwest 42, Purdue 40

No. 13 Indiana (8-0, 5-0) at Michigan State (4-4, 2-3)

Game details: 12:30 p.m. PT Saturday at Spartan Stadium in East Lansing, Michigan

TV channels and live stream: peacock

Latest line: Indiana at 8

Over/Under: 53.5

Predictions

Ryan Clarke: Indiana 37, Michigan State 10

James Crepea: Indiana 35, Michigan State 21

Nick Daschel: Indiana 41, Michigan State 21

Aaron Fentress: Indiana 33, Michigan State 19

Joe Freeman: Indiana 30, Michigan State 24

Sean Meagher: Indiana 42, Michigan State 14

Joel Odom: Indiana 30, Michigan State 20

Bill Oram: Indiana 31, Michigan State 10

UCLA (2-5, 1-4) at Nebraska (5-3, 2-3)

Game details: 12:30 p.m. PT Saturday at Memorial Stadium in Lincoln, Nebraska

TV channels and live stream: Big Ten Network and Fox Sports Live

Latest line: Nebraska at 7

Over/Under: 39.5

Predictions

Ryan Clarke: Nebraska 30, UCLA 20

James Crepea: Nebraska 31, UCLA 17

Nick Daschel: Nebraska 21, UCLA 20

Aaron Fentress: Nebraska 27, UCLA 17

Joe Freeman: Nebraska 25, UCLA 17

Sean Meagher: Nebraska 30, UCLA 17

Joel Odom: Nebraska 38, UCLA 21

Bill Oram: Nebraska 35, UCLA 13

Wisconsin (5-3, 3-2) at Iowa (5-3, 3-2)

Game details: 4:30 p.m. PT Saturday at Kinnick Stadium in Iowa City, Iowa

TV channels and live stream: NBC and Peacock

Latest line: Iowa by 2.5

Over/Under: 41.5

Predictions

Ryan Clarke: Wisconsin 28, Iowa 10

James Crepea: Iowa 24, Wisconsin 21

Nick Daschel: Wisconsin 26, Iowa 22

Aaron Fentress: Wisconsin 26, Iowa 24

Joe Freeman: Wisconsin 23, Iowa 21

Sean Meagher: Iowa 23, Wisconsin 20

Joel Odom: Iowa 20, Wisconsin 17

Bill Oram: Iowa 37, Wisconsin 28

USC (4-4, 2-4) at Washington (4-4, 2-3)

Game details: 4:30 p.m. PT Saturday at Husky Stadium in Seattle

TV channels and live stream: Big Ten Network and Fox Sports Live

Latest line: USC by 1.5

Over/Under: 55.5

Predictions

Ryan Clarke: Washington 20, USC 17

James Crepea: USC 35, Washington 28

Nick Daschel: USC 38, Washington 31

Aaron Fentress: Washington 31, USC 20

Joe Freeman: USC 30, Washington 27

Sean Meagher: USC 28, Washington 21

Joel Odom: USC 31, Washington 20

Bill Oram: Washington 24, USC 21